Polynucleotide treatments are a newer category of regenerative skin booster, using purified polynucleotide fragments, often derived from salmon, to support hydration, skin quality and collagen over a short course of injections. They are not fillers and do not add volume, so the look is improved skin rather than a changed shape. In Sydney they are best known under brand names such as Rejuran, offered through doctor led cosmetic clinics. This page sets out where to find polynucleotides locally, what to expect, the honest risks and downtime, and indicative prices.
Polynucleotide treatments, often marketed as Rejuran, are increasingly offered across Sydney by cosmetic and skin clinics, many in the eastern suburbs and the CBD. Providers that list them among their treatments include Clinical Skin Station in Paddington, The Manse Clinic, Shape Clinic and Contour Clinics, with Laser Clinics Australia also offering Rejuran at selected locations. In Australia these injectable treatments are provided in a medical setting and prescribing is regulated, so a consultation with a qualified practitioner comes first. Because this is a developing treatment category, ask which product is used and what evidence supports it for your concern. Confirm the practitioner's credentials, the product and current pricing with any clinic before booking, as these details change and are best treated as to be confirmed until verified directly.
A good Sydney practitioner explains that polynucleotides improve skin quality rather than add volume, and checks that your goals match what the treatment can do. If you want lift or shape, they should say a different treatment suits you better.
The product is delivered through a series of small injections across the treatment area, taking around twenty to thirty minutes. Numbing cream helps. Small raised bumps at the injection points are normal and usually settle within a day or so.
A typical plan is around three sessions spaced a few weeks apart, with improvements in hydration, glow and texture building over the following months. Maintenance sessions are usually suggested to sustain the effect.
One treatment of the face, in Australian dollars, with the exact figure depending on the product and area.
The recommended starting course, often bundled at a lower per session rate than single visits.
A more focused treatment such as the under eye area, priced per session.
These figures are indicative and quoted in Australian dollars, and they vary by Sydney clinic, the product and the area treated. Treat any single quote as to be confirmed until set out in writing. A course is the usual way this treatment is sold, so ask what a full plan costs rather than a single session. Confirm the product and the full cost at your consultation.
Polynucleotide treatment is generally well tolerated but it is still a series of injections, so expect redness, swelling, small raised bumps at the injection points, tenderness and the occasional bruise for a day or two. As with any injectable, there is a small risk of infection or a localised reaction at the site. Because many polynucleotide products are derived from salmon or fish sources, anyone with a fish allergy should raise this clearly at consultation. This is a relatively new treatment, so the long term evidence base is still building, and honest practitioners present it as promising rather than proven for every concern. It is generally avoided in pregnancy and breastfeeding, with active skin infection, and where there is a relevant allergy. Results develop gradually, vary from person to person and are not guaranteed.
Be clear that this treats skin quality, not volume or lift. Mention any fish allergy, ask which product is used and what realistic improvement to expect, and treat strong before and after promises with caution given the developing evidence. Read the full treatment guide before deciding.
polynucleotides treatment guide →Looking wider? See the Sydney city guide for vetted providers across the city.
Medical disclaimer. Polynucleotide treatment is a medical aesthetic procedure delivered by injection. This page is general information, not medical advice. Prices are indicative and results vary from person to person. Suitability, technique and risks should be assessed in person by a qualified, registered practitioner. Confirm all details with the provider before booking.
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