A medical aesthetic treatment. Polynucleotide treatments inject purified DNA fragments into the skin to support repair and hydration, and should be performed by a qualified medical injector after a proper assessment. This page is general information, not medical advice. Suitability, results and risks vary between people. Always consult a qualified practitioner and confirm current details with the provider before booking.
Toronto clinics have taken up polynucleotides quickly, often under product names such as Rejuran, as a regenerative step that sits apart from filler.
Polynucleotides are short, purified fragments of DNA, usually derived from salmon or trout, injected into the skin to encourage the body's own repair and to improve hydration, firmness and overall quality. They are not a filler and they do not add volume in the way hyaluronic acid does. Instead they work gradually at a cellular level, which is why results build over weeks rather than appearing at once. In Toronto the treatment is offered across medical aesthetic clinics and medspas, frequently under brand names such as Rejuran, and it is often chosen for the under eye area, crepey skin and a general loss of glow. Because it is a newer treatment, an honest clinic is clear that the evidence base is still developing and that a course of sessions is usually needed. Look for a medical injector who explains what polynucleotides can realistically do for your skin and what they cannot.
What to expect
On the day
After numbing, the solution is placed through a series of small injections across the treatment area, sometimes with a fine needle and sometimes a cannula. A session is fairly quick, often twenty to thirty minutes, and is usually repeated as a short course.
Downtime
Small bumps, redness and tenderness at the injection points are normal and usually settle within a day or two. Bruising is possible, more so around the eyes. Most people return to daily life quickly but may plan a session a week or so before an event.
How long it lasts
A typical plan is two to four sessions a few weeks apart, with skin quality improving gradually and full effect taking around three months. Benefits are not permanent and maintenance sessions are usual. Results vary between people and the treatment suits skin quality rather than deep lines or volume loss.
Real risks and downtime
Polynucleotides are generally well tolerated, and most effects are mild and short lived, such as redness, swelling, small lumps, tenderness and bruising at the injection sites. As with any injectable that breaks the skin, there is a small risk of infection, and rarely a persistent lump or a reaction to the product. People with an allergy to fish should raise this, given the source of the material. Because it is a newer treatment, the long term evidence is still building, and an honest clinic will not overstate what it can do or promise a fixed outcome. It is not a substitute for filler where volume is the issue, nor for anti wrinkle injections where movement is the cause of a line. A careful injector assesses whether your concern is one polynucleotides actually address, and sets expectations around a course rather than a single visit.
Toronto clinics worth knowing
A starting point, not a ranking. These are real, established Toronto practices that work in this area. Confirm current practitioners, products and prices directly with each provider.
ID Cosmetic Clinic
A Toronto clinic offering polynucleotide skin rejuvenation, including Rejuran, with treatment led by physicians. Confirm current practitioners, the specific product and pricing with the practice.
Aesthetics by Aman
A medical aesthetics practice offering polynucleotide treatments for skin regeneration and elasticity across the Greater Toronto Area. Verify current details and pricing with the practice.
VBeauty Medical Spa
A medical spa offering polynucleotide based skin booster treatments that pair the active with hyaluronic acid. Treatment availability and current prices to be confirmed with the practice.
The Face Lab
A skin clinic on Dundas West offering advanced medical aesthetic treatments. Confirm whether polynucleotide injectables are currently offered, who performs them, and pricing with the practice.
Indicative Toronto pricing
One polynucleotide session for an area such as the face or under eyes.
A typical course of three sessions, often priced as a package, spaced a few weeks apart.
These figures are indicative ranges and not quotes. Price varies with the brand used, the area treated and the number of sessions, and a course is usually needed for a meaningful result. A consultation with the injector should come first. Confirm current prices with each clinic.
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