A regenerative injectable, not a filler
Polynucleotides are fragments of purified DNA, typically derived from salmon or trout, injected into the skin to support repair and hydration rather than to add volume. Unlike a hyaluronic acid filler, they are a biostimulator, intended to improve skin quality, elasticity and hydration gradually over a course of sessions. A typical plan is two to four treatments a few weeks apart, with results building slowly. They are often discussed for under eye skin quality, overall facial freshness and as part of regenerative skin protocols. It is a treatment of refinement, not dramatic change, and managing expectations is part of doing it well.
Local availability and the regulatory picture
Polynucleotide and salmon DNA skin treatments are offered by a small number of New York practices, frequently under the Rejuran name, and usually performed by physicians or experienced injectors. It is important to be clear eyed about the regulatory position: as of early 2025, polynucleotide injectables were not approved by the United States Food and Drug Administration for this use, and availability and product sourcing can vary between practices. This makes it especially important to ask your provider directly which product they use, where it is sourced, and how they handle consent and safety. Among the New York practices that have offered this treatment are the following, listed as a research starting point.
Anna Avaliani MD
A New York cosmetic and laser practice that has promoted Rejuran salmon DNA skin booster treatments. Current product, protocol, pricing and suitability to be confirmed at consultation.
New Face NY
A New York facial plastic surgery practice led by a double board certified surgeon that has listed polynucleotide treatments. Current product, protocol, pricing and suitability to be confirmed directly.
Little Laser Clinic, Long Island City
A Long Island City practice that has offered Rejuran skin rejuvenation, with treatment by an experienced physician associate. Current product, protocol, pricing and suitability to be confirmed when you book.
Listed as a research starting point, not a ranking anyone has paid for. Given the evolving regulatory position in the United States, always confirm the exact product, its sourcing and regulatory status, the treating practitioner, current pricing and your suitability directly with the practice.
What it tends to cost in New York
Where offered in New York, polynucleotide or Rejuran sessions tend to run from around 600 dollars to 1,200 dollars per session, with most protocols recommending a course of two to four. Pricing varies with the practice, the practitioner and the area treated, and package pricing for a course is common. Because this is a treatment with an evolving regulatory picture in the United States, price should never be the deciding factor over the credentials of the practice and the clarity of what is being injected. Treat these figures as a sense of scale, not a quote.
Polynucleotides are an injectable treatment and carry real risks. Common effects include redness, swelling, bruising, small bumps at the injection sites and tenderness, usually settling over a few days. Less common risks include infection and allergic reaction, and because the product is derived from fish, anyone with a fish allergy should raise this clearly beforehand. There is also a broader consideration: in the United States this product class was not FDA approved for injection as of early 2025, so the usual regulatory safeguards may not apply, and long term data is more limited than for established treatments. Downtime is usually mild. This page is general information, not medical advice. Results vary and no outcome can be guaranteed. A proper assessment with a qualified practitioner, including a frank discussion of the product's regulatory status, is essential before treatment.
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