A medical aesthetic treatment. Polynucleotides are injected into the skin to support hydration and quality and are best administered by a qualified medical practitioner. This page is general information, not medical advice. Suitability, results and risks vary between people. Always consult a qualified practitioner and confirm current details with the provider before booking.
Monaco sits at the centre of regenerative aesthetics, hosting the field's leading congress each spring.
Polynucleotides are chains of purified DNA fragments, often derived from salmon or trout, injected into the skin to support hydration, elasticity and overall skin quality rather than to add volume like a traditional filler. The idea is bioregeneration, encouraging the skin to behave a little younger over a course of sessions. Monaco is a natural home for this conversation, hosting the Aesthetic and Anti Aging Medicine World Congress each year, where polynucleotides and skin boosters feature heavily. The principality and neighbouring Beausoleil are served by discreet aesthetic medicine practices used to an international clientele. Polynucleotides are still a newer category, so it is worth confirming directly with a clinic whether they offer this specific treatment and which product they use. Choose a medical practitioner who explains the realistic gains honestly and treats over a planned course rather than promising a single dramatic change.
What to expect
On the day
After cleansing and often a numbing cream, a series of small injections places the product across the treatment area, sometimes including the under eye, cheeks or neck. Most describe small stings. The appointment usually takes around thirty minutes.
Downtime
Expect small raised bumps at the injection points that settle within a day, with possible redness or a little bruising. Many return to normal activity the same day, avoiding heavy exercise and heat for a day or two.
The course
A typical plan is around three sessions spaced a few weeks apart, with maintenance every few months. Results build gradually as skin quality improves and vary from person to person.
Real risks and downtime
Common and usually temporary effects include redness, small bumps, swelling, tenderness and the chance of bruising at the injection points. As with any injectable, there is a small risk of infection, and a responsible clinic works in clean conditions and gives aftercare advice. Because many polynucleotide products are derived from fish, they are generally avoided in anyone with a relevant fish allergy, and the treatment is typically avoided in pregnancy and breastfeeding and where there is active skin infection in the area. Polynucleotides improve skin quality gradually and subtly, so anyone expecting the lift or volume of a filler will be disappointed. The evidence base is growing but still developing. Results vary and are never guaranteed. A responsible practitioner sets honest expectations and confirms the product and protocol with you.
Monaco clinics worth knowing
A starting point, not a ranking. These are real, established aesthetic medicine practices serving Monaco and its immediate surroundings. Polynucleotide availability is a newer offering, so confirm the specific treatment, product and prices directly with each provider.
Pavillon Esthetic, Dr Emmanuel Antoni
An aesthetic and laser medicine practice led by Dr Emmanuel Antoni in Beausoleil, on the border of Monaco, offering injectable skin boosters and regenerative treatments. Confirm polynucleotide availability and pricing with the practice.
Richmont Monaco
A Monte Carlo institute offering personalised, non invasive aesthetic treatments aimed at improving skin quality. Confirm whether polynucleotide treatment is offered, along with pricing, directly with the institute.
Aesthetic medicine practitioners around Monaco
Given Monaco's small size, many residents also see established aesthetic doctors in nearby Nice and along the Cote d Azur. Specific clinics and polynucleotide availability to be confirmed. We can help you identify a vetted practitioner.
Indicative Monaco pricing
A single session, varying by area, product and practitioner.
A typical initial course, often offered as a package. Monaco pricing sits at the higher end.
These figures are indicative ranges and not quotes. Because the treatment works over a course, plan for the total rather than a single session, and remember this is a subtle skin quality treatment. Confirm current prices and the product used with each practice.
Find your Monaco clinic.
Tell us what you are considering. We will introduce you to vetted Monaco practitioners. No pressure, no obligation.
A quiet letter, once a month.
Considered guidance on treatments and clinics worth knowing, with no hype. Subscribe to The Beauty Edit.